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Description: SCR-1481B1 (also known as c-Met inhibitor 2) is a novel potent and selective MET inhibitor. SCR-1481B1 inhibited MET kinase with IC50 value of 1.7 nM. It has potential anticancer activities. SCR-1481B1 is a potent compound that has activity against cancers dependent upon Met activation and also has activity against cancers as a VEGFR inhibitor. The chemical name is 3-amino-3-(2-hydroxyethyl)pentane-1, 5-diol (3-((4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)carbamoyl)-5-(4-fluorophenyl)-4-oxopyridin-1(4H)-yl)methyl phosphate.
References: WO/2009094417/A1.
Related CAS: 1174161-69-3 (free)
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