KS176

Item no.	V3037-250mg
Manufacturer	InvivoChem LLC
CASRN	1253452-78-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #: V3037CAS #:1253452-78-6Purity >=98% Description: KS176 is a novel potent and highly selective/specific inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter with IC50 values of 0.59 and 1.39 uM in Pheo A and Hoechst 33342 assays respectively. It displays no inhibitory activity against P-gp or MRP1. KS176 and its analogs share a noncompetitive-type interaction with pheophorbide A. Experiments with imatinib and pheophorbide A revealed a mixed-type interaction. This class of specific breast cancer resistance protein (BCRP) inhibitors showed no inhibition of the ATP binding cassette (ABC) transporters P-gp and MRP1. Some of these modulators inhibit BCRP with high potency; they are only slightly less potent than Ko143 and could serve as promising lead structures for the design of novel effective BCRP inhibitors. These inhibitors are structurally related to tariquidar (XR9576) and belong to a library of multidrug-resistance modulators Description: References: ChemMedChem. 2010 Sep 3; 5(9):1498-505. References:
Molecular Weight (MW)	405.4
Formula	C22H19N3O5
CAS No.	1253452-78-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 35 mg/mL
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	O=C(NC1=CC=C(CCO)C=C1)C2=CC=CC=C2NC(C3=CC=C([N+]([O-])=O)C=C3)=O
Synonyms	KS-176; KS176; KS 176

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Amount: 250 mg

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