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Description: ICA 110381 (Compound 16) is a potent KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 uM) as well as KCNQ1 antagonist (IC50=15 uM).
References: Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31; 2(6):481-4.
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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.
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