BMS-1

Item no.	V3097-100mg
Manufacturer	InvivoChem LLC
CASRN	1675201-83-8
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3097CAS #:1675201-83-8Purity >=98% Description: BMS-1 (also known as PD1-PDL1-IN1, or PD1/PD-L1 inhibitor 1) is a novel and highly potent small molecule inhibitor of PD-1/PD-L1 protein/protein interaction with an IC50 of 6 nM. It was first discovered by BMS (Bristol-Myers-Squibb) as an immunomodulator for the Programmed death-ligand 1 (PD-L1) with potential anticancer activities. PD-L1 is known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. It is reported that the overexpression of PD-L1 may allow cancers to escape the surveilance of host immune system. Description: References: WO/2015/034820; J Med Chem. 2017 Jul 13; 60(13):5857-5867. References:
Molecular Weight (MW)	475.58
Formula	C29H33NO5
CAS No.	1675201-83-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 95 mg/mL (199.7 mM)
	Water: 95 mg/mL (199.7 mM)
	Ethanol: N/A
SMILES Code	O=C([CH]1N(CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC)CCCC1)O
Synonyms	PD1/PDL1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; PD1-PDL1-IN1; BMS-1; BMS 1; BMS1

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Amount: 100 mg

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