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SSR-240612 HCl

SSR-240612 HCl

Item no.	V3106-100mg
Manufacturer	InvivoChem LLC
CASRN	464930-42-5
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3106CAS #:464930-42-5Purity >=98% Description: SSR-240612 HCl, the hydrochloride salt of SSR-240612, is a novel, potent, and orally bioactive specific non-peptide bradykinin B(1) receptor antagonist. SSR-240612 has the potential for the treatment of inflammation and chronic pain. SSR240612 acts by inhibiting the binding of (3)HLys(0)-des-Arg(9)-BK to the B(1) receptor in human fibroblast MRC5 and to recombinant human B(1) receptor expressed in human embryonic kidney cells with inhibition constants (K(i)) of 0.48 and 0.73 nM, respectively. SSR240612 inhibited Lys(0)-desAr(9)-BK (10 nM)-induced inositol monophosphate formation in human fibroblast MRC5, with an IC(50) of 1.9 nM. It also antagonized des-Arg(9)-BK-induced contractions of isolated rabbit aorta and mesenteric plexus of rat ileum with a pA(2) of 8.9 and 9.4, respectively. Description: References: Regul Pept. 2009 Jan 8; 152(1-3):67-72; J Pharmacol Exp Ther. 2004 May; 309(2):661-9. References: Related CAS#: 465539-70-2 (free base)
Molecular Weight (MW)	793.42
Formula	C42H53ClN4O7S
CAS No.	464930-42-5 (HCl); 465539-70-2 (free base)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 100 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	D-Phenylalaninamide, (3S)-3-(1, 3-benzodioxol-5-yl)-N-((6-methoxy-2-naphthalenyl)sulfonyl)-beta-alanyl-4-(((2R, 6S)-2, 6-dimethyl-1-piperidinyl)methyl)-N-methyl-N-(1-methylethyl)-, hydrochloride (1:1)
Synonyms	SSR-240612 hydrochloride; SSR 240612; SSR240612 HCl
SMILES Code	O=C(NC([CH](C1=CC=C(OCO2)C2=C1)CNS(=O)(C3=CC=C4C=C(OC)C=CC4=C3)=O)=O)[CH](CC5=CC=C(CN6[CH](C)CCC[CH]6C)C=C5)N(C)C(C)C.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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