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CCG-203971

CCG-203971

Item no.	V3118-50mg
Manufacturer	InvivoChem LLC
CASRN	1443437-74-8
Amount	50 mg
Quantity options	100 mg 10 mg 1 g 250 mg 25 mg 500 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3118CAS #:1443437-74-8 Purity >=98% Description: CCG-203971 is a novel, 2nd generation small-molecule inhibitor of the Rho/MRTF/SRF RhoA/myocardin-related transcription factor A (MRTF-A) pathway with an IC50 value of 0.64 uM for SRE. CCG-203971 inhibits expression of connective tissue growth factor (CTGF), alpha-smooth muscle actin (alpha-SMA), and collagen 1 (COL1A2) in both SSc fibroblasts and in lysophosphatidic acid (LPA)-and transforming growth factor beta (TGFbeta)-stimulated fibroblasts. CCG-203971 significantly represses TGF-beta- induced MKL1 expression at 25 uM concentration. Description: References: J Pharmacol Exp Ther. 2014 Jun; 349(3):480-6; Bioorg Med Chem Lett. 2017 Apr 15; 27(8):1744-1749. References:
Molecular Weight (MW)	408.88
Formula	C23H21ClN2O3
CAS No.	1443437-74-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 81 mg/mL (198.1 mM)
	Water: < 1mg/mL
	Ethanol: 4 mg/mL (9.8 mM)
Solubility (In vivo)	10% DMSO : 40% PEG300 : 5% Tween-80 : 45% saline: >= 2.5 mg/mL
Synonyms	CCG203971; CCG 203971; CCG-203971.
SMILES Code	O=C(C1CN(C(C2=CC=CC(C3=CC=CO3)=C2)=O)CCC1)NC4=CC=C(Cl)C=C4

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 mg

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