« Back
Home /
Chk2 Inhibitor II (BML-277)

Chk2 Inhibitor II (BML-277)

Item no.	V3119-100mg
Manufacturer	InvivoChem LLC
CASRN	516480-79-8
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3119CAS #:516480-79-8Purity >=98% Description: Chk2 Inhibitor II (also known as BML-277) is an ATP-competitive inhibitor of Chk2 (checkpoint kinase 2) with an IC50 of 15 nM. It is 1000-fold more selective towards Chk2 than Chk1 and Cdk1/B kinases. BML-277 dose dependently protects human CD4+ and CD8+ T-cells from apoptosis due to ionizing radiation. It can efficiently rescue both T-cell populations from radiation-induced apoptosis in a dose-dependent manner with an observed EC50 of 3?7.6 uM. The concentration of BML-277 required for radioprotection is consistent with the biochemical measurement of chk2 inhibition. Description: References: J Med Chem. 2005 Mar 24; 48(6):1873-85; Nat Commun. 2011 Jul 19; 2:402. References: Related CAS#:516480-80-1 (BML277 Acid, a metabolite of BML277)
Molecular Weight (MW)	363.80
Formula	C20H14ClN3O2
CAS No.	516480-79-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 72 mg/mL (197.9 mM)
	Water: < 1mg/mL
	Ethanol: 21 mg/mL (57.7 mM)
Chemical Name	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
Synonyms	BML-277; BML277; Chk2 Inhibitor II; C 3742
SMILES Code	O=C(C1=CC=C2C(N=C(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)N2)=C1)N

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 9/4/2025

Express Delivery: Save 8 days

Compare

Add to wishlist

Get an offer