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ly333531-mesylate

ly333531-mesylate

Item no.	V3124-25mg
Manufacturer	InvivoChem LLC
CASRN	192050-59-2
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3124CAS #:192050-59-2 Purity >=98% Description: Ruboxistaurin mesylate (LY333531 mesylate) is a specific inhibitor of PKCbeta (protein kinase C). It competitively and reversibly inhibits PKCbeta1 and PKCbeta2 with IC50 values of 4.7 and 5.9 nM respectively. It has the usefulness to treat diabetic nephropathy and diabetic macular edem. LY333531 strikingly decreases the chance of HUVEC survival and the effect of LY333531 on apoptotic cell death in HUVEC significantly increases compared with the AGEs group. Blockade of PKC-beta up-regulates the expression of Bax and Bad proteins and down-regulates the expression of Bcl-2 protein. Moreover, LY333531 reduces the ratio of Bcl-2/Bax. Description: References: J Med Chem. 1996 Jul 5; 39(14):2664-71; Diabetes. 2013 Jul; 62(7):2318-28; Pharmazie. 2011 Nov; 66(11):881-7. References: Related CAS#: 169939-94-0 (free base); 202260-21-7 (mesylate hydrate); 192050-59-2 (mesylate) 169939-93-9 (HCl)
Molecular Weight (MW)	564.66
Formula	C29H32N4O6S
CAS No.	192050-59-2 (mesylate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: N/A
	Water: N/A
	Ethanol: N/A
Other info	Chemical Name: (9S)-9-[(Dimethylamino)methyl]-6, 7, 10, 11-tetrahydro-9H, 18H-5, 21:12, 17-dimethenodibenzo[e, k]pyrrolo[3, 4-h][1, 4, 13]oxadiazacyclohexadecine-18, 20(19H)-dione mesylate InChi Key: DUHQBKLTAVUXFF-FERBBOLQSA-N InChi Code: InChI=1S/C28H28N4O3.CH4O3S/c1-30(2)15-18-11-12-31-16-21(19-7-3-5-9-23(19)31)25-26(28(34)29-27(25)33)22-17-32(13-14-35-18)24-10-6-4-8-20(22)24; 1-5(2, 3)4/h3-10, 16-18H, 11-15H2, 1-2H3, (H, 29, 33, 34); 1H3, (H, 2, 3, 4)/t18-; /m0./s1 SMILES Code: O=C1NC(C(C2=CN(C3=CC=CC=C32)CCO[CH](CN(C)C)CC4)=C1C5=CN4C6=CC=CC=C56)=O.OS(=O)(C)=O
Synonyms	LY-333531 Mesylate; Ruboxistaurin mesylate; LY-333531; LY333531; LY 333531; LY-333531 Mesylate

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Amount: 25 mg

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Delivery expected until 10/2/2025

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