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norcantharidin

norcantharidin

Item no.	V3133-50mg
Manufacturer	InvivoChem LLC
CASRN	5442-12-6
Amount	50 mg
Quantity options	100 mg 10 g 1 g 250 mg 25 g 25 mg 500 mg 5 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3133CAS #:29745-04-8Purity >=98% Description: Norcantharidin (also known as NCTD) is a dual inhibitor of c-Met and EGFR. It has anticancer activity and can induce cell cycle arrest at G2/M phase in HCT116 and HT29 cells. NCTD inhibits not only the expression of the total EGFR and the p-EGFR (phosphorylated EGFR) but also the expression of the total c-Met and the pc-Met (phosphorylated c-Met) in colon cancer cells. Norcantharidin is also an inhibitor of protein phosphatase types 1, 2A and 2B, and can arrest the cell cycle at G2/M phase in K562 human myeloid leukemia cells, and inhibit DNA synthesis in HL-60 cells. Description: References: BMC Cancer. 2017 Jan 13; 17(1):55; Hepatobiliary Pancreat Dis Int. 2010 Aug; 9(4):414-22. References:
Molecular Weight (MW)	168.15
Formula	C8H8O4
CAS No.	29745-04-8
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 33 mg/mL (196.3 mM)
	Water:
	Ethanol:
Solubility (In vivo)
Synonyms	Endothall anhydride
SMILES Code

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Amount: 50 mg

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Delivery expected until 10/2/2025

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