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Description: Valproic acid is an HDAC (Histone deacetylase) inhibitor used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. Valproic Acid is a fatty acid with anticonvulsant properties by selectively inducing proteasomal degradation of HDAC2. It may act by increasing gamma-aminobutyric acid levels in the brain or by altering the properties of voltage dependent sodium channels. It is also under investigation for treatment of HIV and various cancers.
References: J Biol Chem. 2001 Sep 28; 276(39):36734-41; EMBO J. 2001 Dec 17; 20(24):6969-78; Oncol Rep. 2013 Dec; 30(6):2999-3005.
Related CAS#:1069-66-5 (Sodium salt)
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