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Simeprevir

Simeprevir

Item no.	V3154-25mg
Manufacturer	InvivoChem LLC
CASRN	923604-59-5
Amount	25 mg
Quantity options	100 mg 10 mg 1 g 250 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3154CAS #:923604-59-5Purity >=98% Description: Simeprevir (previously known as TMC43) is a competitive, reversible, macrocyclic, noncovalent inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It acts directly against the hepatitis C virus and has been approved by the US FDA for use in combination with peginterferon-alfa and ribavirin to treat hepatitis C and hepatitis B. Simeprevir has also received approval in Japan for the treatment of chronic hepatitis C infection, genotype 1. It has a medium inhibitory concentration with IC50< 13 nM for all HCV NS3/4A enzymes (genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3. Description: References: Pharmgenomics Pers Med. 2014; 7: 241–249; Bioorg Med Chem Lett. 2008 Sep 1; 18(17):4853-8. References:
Molecular Weight (MW)	749.94
Formula	C38H47N5O7S2
CAS No.	923604-59-5; 1241946-89-3 (sodium);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (133.3 mM)
	Water: < 1 mg/mL
	Ethanol: 4 mg/mL (5.3 mM)
Chemical Name	sodium (cyclopropylsulfonyl)((2R, 3aR, 11aS, 12aR, 14aR, Z)-2-((2-(4-isopropylthiazol-2-yl)-7-methoxy-8-methylquinolin-4-yl)oxy)-5-methyl-4, 14-dioxo-1, 2, 3, 3a, 4, 5, 6, 7, 8, 9, 11a, 12, 12a, 13, 14, 14a-hexadecahydrocyclopenta[c]cyclopropa[g][1, 6]diazacyclotetradecine-12a-carbonyl)amide
Synonyms	Simeprevir; Olysio; TMC-435; TMC 435; TMC435; TMC-435350; TMC 435350; TMC435350;
SMILES Code	COC1=C(C)C2=C(C(O[CH]3CC(C(N(C)CCCC/C=C\[CH](C4)[C]4(C(NS(=O)(C5CC5)=O)=O)N6)=O)[CH](C6=O)C3)=CC(C7=NC(C(C)C)=CS7)=N2)C=C1

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Amount: 25 mg

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Delivery expected until 9/4/2025

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