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Simeprevir sodium

Simeprevir sodium

Item no.	V3155-100mg
Manufacturer	InvivoChem LLC
CASRN	1241946-89-3
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3155CAS #:1241946-89-3Purity >=98% Description: Simeprevir sodium, the sodium salt of simeprevir (previously known as TMC43), is a competitive, reversible, macrocyclic, noncovalent inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It acts directly against the hepatitis C virus and has been approved by the US FDA for use in combination with peginterferon-alfa and ribavirin to treat hepatitis C and hepatitis B. Simeprevir has also received approval in Japan for the treatment of chronic hepatitis C infection, genotype 1. It has a medium inhibitory concentration with IC50< 13 nM for all HCV NS3/4A enzymes (genotypes 1a, 1b, 2, 4, 5, and 6), but has an IC50 value of 37 nM for genotype 3. Description: References: Pharmgenomics Pers Med. 2014; 7: 241–249; Bioorg Med Chem Lett. 2008 Sep 1; 18(17):4853-8. References: Related CAS#: 923604-59-5 (free acid)
Molecular Weight (MW)	771.92
Formula	C38H46N5O7NaS2
CAS No.	1241946-89-3 (sodium salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL (133.3 mM)
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	N/A
Synonyms	TMC-435; TMC 435; TMC435; TMC-435350; Olysio
SMILES Code	O=C([N-]S(=O)(C1CC1)=O)[C]23NC([C](C[CH](OC4=CC(C5=NC(C(C)C)=CS5)=NC6=C(C)C(OC) =CC=C46)C7)([H])[C]7([H])C(N(C)CCCC/C=C\[C]2([H])C3)=O)=O.[Na+]

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Amount: 100 mg

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Delivery expected until 10/2/2025

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