Esomeprazole Magnesium trihydrate

Description: EsomeprazoleMagnesium trihydrate (S-Omeprazole magnesium trihydrate) is a proton pump inhibitor (PPI)that is used to reduce gastric acid secretion. Esomeprazole Magnesium isthe magnesium salt of esomeprazole, the S-isomer of omeprazole. In theacidic compartment of parietal cells, esomeprazole is protonated andconverted into the active achiral sulphenamide; the active sulphenamideforms one or more covalent disulfide bonds with the proton pumphydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), therebyinhibiting its activity and the parietal cell secretion of H+ ions intothe gastric lumen.

References: Expert Opin Pharmacother. 2003 Feb; 4(2):253-64.

Related CAS#: 95510-70-6(sodium); 119141-88-7 (S-isomer); 95510-71-7 (potassium); 73590-85-9(Omeprazole metabolite Omeprazole sulfide; Ufiprazole; Omeprazolesulfide); 88546-55-8 (Omeprazole metabolite Omeprazole sulfone; Omeprazole sulfone; Omeprazole sulphone); 922731-01-9 (Omeprazole D3; H16868 D3); 73590-58-6 (free form); 161973-10-0 (Esomeprazole magnesium); 217087-09-7 (Esomeprazole Magnesium trihydrate)