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Grazoprevir hydrate

Grazoprevir hydrate

Item no.	V3160-500mg
Manufacturer	InvivoChem LLC
CASRN	1350462-55-3
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3160CAS #:1350462-55-3 Purity >=98% Description: Grazoprevir hydrate (previously known as MK5172), the mono-hydrate form of grazoprevir, is a second generation, potent and selective inhibitor of the Hepatitis C Virus NS3/4A Protease with IC50 values of 7pM, 4pM, and 62pM for HCV genotype 1a, 1B, and 4 respectively. Grazoprevir has been approved by FDA for the treatment of hepatitis C. It has a broad spectrum of activity across genotypes and resistant variants. Grazoprevir was originally developed by Merck with promising results in Phase II/III when used in combination with the NS5A replication complex inhibitor elbasvir, either with or without ribavirin. Grazoprevir acts at the NS3/4a protease sites with good activity against a range of HCV genotype variants, including some resistant variant that are resistant to most currently used antiviral drugs. Description: References: Antimicrob Agents Chemother. 2012 Aug; 56(8):4161-7; ACS Med Chem Lett. 2012 Mar 2; 3(4):332-6. References: Related CAS#:350514-68-9 (free acid); 1206524-86-8 (potassium); 1425038-27-2 (sodium salt)
Molecular Weight (MW)	784.93
Formula	C38H52N6O10S
CAS No.	1350462-55-3 (hydrate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: < 1 mg/mL
	Ethanol: > 100 mg/mL
Other info	Chemical Name: (33R, 35S, 91R, 92R, 5S)-5-(tert-butyl)-N-((1R, 2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-17-methoxy-4, 7-dioxo-2, 8-dioxa-6-aza-1(2, 3)-quinoxalina-3(3, 1)-pyrrolidina-9(1, 2)-cyclopropanacyclotetradecaphane-35-carboxamide hydrate InChi Key: RXSARIJMSJWJLZ-CIAYNJNFSA-N InChi Code: InChI=1S/C38H50N6O9S.H2O/c1-6-22-19-38(22, 35(47)43-54(49, 50)25-13-14-25)42-32(45)29-18-24-20-44(29)34(46)31(37(2, 3)4)41-36(48)53-30-16-21(30)10-8-7-9-11-27-33(52-24)40-28-17-23(51-5)12-15-26(28)39-27; /h6, 12, 15, 17, 21-22, 24-25, 29-31H, 1, 7-11, 13-14, 16, 18-20H2, 2-5H3, (H, 41, 48)(H, 42, 45)(H, 43, 47); 1H2/t21-, 22-, 24-, 29+, 30-, 31-, 38-; /m1./s1
Synonyms	MK5172; MK 5172; MK-5172 hydrate, Trade name: Zepatier?.
SMILES Code	COC1=CC2=C(N=C(CCCCC[CH]3C[CH]3OC4=O)C(O[CH]5CN(C([CH](C(C)(C)C)N4)=O)[CH](C(N[C]([CH]6C=C)(C6)C(NS(C7CC7)(=O)=O)=O)=O)C5)=N2)C=C1.O

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Amount: 500 mg

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Delivery expected until 9/4/2025

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