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vildagliptin-dihydrate

vildagliptin-dihydrate

Item no.	V31661-250mg
Manufacturer	InvivoChem LLC
CASRN	2133364-01-7
Amount	250 mg
Quantity options	100 mg 1 g 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V31661CAS #:2133364-01-7Purity >=98% Description: Vildagliptin (LAF237 dihydrate; NVP-LAF 237 dihydrate) is a selective dipeptidyl peptidase 4 (DPP4) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. It delays the degradation of glucagon-like peptide-1 (GLP-1).Vildagliptin dihydrate possesses excellent oral bioavailability andpotent antihyperglycemic activity. References: 1. ChengQ, et al. Combination of the dipeptidyl peptidase IV inhibitor LAF237(S)-1-(3-hydroxy-1-adamantyl)ammoacetyl-2-cyanopyrrolidine with theangiotensin II type 1 receptor antagonist valsartanN-(1-oxopentyl)-N-2'-(1H-tetrazol-5-yl)-1, 1'-biphenyl-4-ylmethyl-L-valineenhances pancreatic islet morphology and function in a mouse model oftype 2 diabetes. J Pharmacol Exp Ther. 2008 Dec; 327(3):683-91. 2. ShenM, et al. The synergistic effect of valsartan and LAF237(S)-1-(3-hydroxy-1-adamantyl)ammoacetyl-2-cyanopyrrolidine onvascular oxidative stress and inflammation in type 2 diabetic mice. ExpDiabetes Res. 2012; 2012:146194. 3. AbdelhamidAM, et al. Vildagliptin/Pioglitazone Combination Improved The OverallGlycemic Control In Type I Diabetic Rats. Can J Physiol Pharmacol. 2018Mar 6. doi: 10.1139/cjpp-2017-0680.

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Amount: 250 mg

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