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Temuterkib (LY3214996)

Temuterkib (LY3214996)

Item no.	V3178-250mg
Manufacturer	InvivoChem LLC
CASRN	1951483-29-6
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3178CAS #:1951483-29-6 Purity >=98% Description: LY3214996 is a novel, highly potent, selective and orally bioavailable inhibitor of the ERK1 (extracellular signal-regulated kinase) and ERK2, with IC50 value of 5 nM for both enzymes (ERK1/2) in biochemical assays. LY3214996 inhibits both ERK 1 and 2, thereby preventing the activation of the MAPK (mitogen-activated protein kinase)/ERK-mediated signal pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. Therefore, LY-3214996 has the potential to be developed as an antineoplastic drug. LY3214996 also significantly inhibited the growth and migration of the AGO1 cells. Description: References: Cancer Research 77(13 Supplement):3231-3231; Cell Death Dis. 2018 Feb 27; 9(3):324. References:
Molecular Weight (MW)	453.56
Formula	C22H27N7O2S
CAS No.	1951483-29-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 25 mg/mL
	Water: < 1 mg/mL
	Ethanol: 15 mg/mL
Chemical Name	6, 6-dimethyl-2-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)-5-(2-morpholinoethyl)-5, 6-dihydro-4H-thieno[2, 3-c]pyrrol-4-one
Synonyms	LY3214996; LY 3214996; LY-3214996;
SMILES Code	O=C(C(C=C(C1=NC(NC2=CC=NN2C)=NC=C1)S3)=C3C4(C)C)N4CCN5CCOCC5

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Amount: 250 mg

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Delivery expected until 9/4/2025

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