OTS514

Item no.	V3180-250mg
Manufacturer	InvivoChem LLC
CASRN	1338540-63-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3180CAS #:1338540-63-8Purity >=98% Description: OTS514 is a novel and highly potent inhibitor of the TOPK (T-LAK cell-originated protein kinase) with an IC50 value of 2.6 nM. It strongly suppressed the growth of TOPK-positive cancer cells. It also shows significant growth-inhibitory effect on ovarian cancer cell lines with IC50 values of 3.0 to 46 nM. OTS514 displays growth inhibitory effects against small cell lung cancer with IC50 in the range of 0.4 ca. 42.6 nM and can lead to their apoptotic cell death. OTS514 also suppressed forkhead box protein M1 (FOXM1) activity, a protein involved in stemness of CSC. Furthermore, treatment with OTS514 reduced CD90-positive SCLC cells and exhibited higher cytotoxicity against lung sphere-derived CSC-like SCLC cells. References: Clin Cancer Res. 2016 Dec 15; 22(24):6110-6117. Related CAS #: 1338544-87-8 (HBr) 1338540-63-8 (free base) 1338541-25-5 (s-isomer) 1338545-92-8 (S-isomer HCl)
Molecular Weight (MW)	364.46
Formula	C21H20N2O2S
CAS No.	1338540-63-8 (free base); 1338541-25-5 (s-isomer); 1338545-92-8 (S-isomer HCl); 1338544-87-8 (HBr)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water:
	Ethanol:
SMILES Code	O=C1NC2=C(C(C3=CC=C([CH](C)CN)C=C3)=C(O)C=C2C)C4=C1SC=C4
Synonyms	OTS-514; OTS 514; OTS514

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Amount: 250 mg

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