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Pevonedistat HCl (MLN-4924; TAK-924)

Pevonedistat HCl (MLN-4924; TAK-924)

Item no.	V3202-100mg
Manufacturer	InvivoChem LLC
CASRN	1160295-21-5
Amount	100 mg
Quantity options	10 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3202CAS #:1160295-21-5Purity >=98% Description: Pevonedistat HCl (MLN-4924; TAK-924), is a potent and selective small molecule inhibitor of Nedd8 (Neural precursor cell expressed, developmentally down-regulated 8) activating enzyme (NAE) with IC50 of 4 nM. Pevonedistat selectively inhibits NAE activity compared to the closely related ubiquitin-activating enzyme (UAE, also known as UBA1) and SUMO-activating enzyme (SAE; a heterodimer of SAE1 and UBA2 subunits), in purified enzyme and cellular assays. MLN4924 exhibits potent cytotoxic activity against a variety of human tumour-derived cell lines. By binding to and inhibiting NAE, Pevonedistat can inhibit tumor cell proliferation and survival. NAE activates Nedd8, an ubiquitin-like (UBL) protein that modifies cellular targets in a pathway that is parallel to but distinct from the ubiquitin-proteasome pathway (UPP). Description: References: Nature. 2009 Apr 9; 458(7239):732-6; Blood. 2010 Sep 2; 116(9):1515-23; Cell Death Discovery 1, Article number: 15034 (2015) References: Related CAS #: 1160295-21-5 (HCl) 905579-51-3 (free base)
Molecular Weight (MW)	479.98
Formula	C21H26ClN5O4S
CAS No.	1160295-21-5 (HCl); 905579-51-3 (free base)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES Code	[H]Cl.O=S(OC[CH]1[CH](O)C[CH](N2C=CC3=C(N[CH]4CCC5=C4C=CC=C5)N=CN=C32)C1)(N)=O
Synonyms	MLN-4924 HCl; MLN4924 HCl; Pevonedistat HCl; TAK924 HCl; TAK 924 HCl; TAK-924 HCl

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Amount: 100 mg

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Delivery expected until 9/4/2025

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