ML213

Item no.	V3227-500mg
Manufacturer	InvivoChem LLC
CASRN	489402-47-3
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3227CAS #:489402-47-3Purity >=98% Description: ML213 (formerly known as CID-3111211) is a potent and selective activator/opener of Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) channels which enhances Kv7.2 and Kv7.4 channels with EC50 of 230 and 510 nM, respectively. ML213 shows more than 80-fold selectivity for Kv7.2 (KCNQ2) and Kv7.4 (KCNQ4) versus a large battery of related potassium channels such as KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay, it also can afford modest brain levels. ML213, as a potent vasorelaxant in different blood vessels, may have the potential to be developed as therapeutics for various smooth muscle disorders. Description: References: ACS Chem Neurosci. 2011 Oct 19; 2(10):572-577; Br J Pharmacol. 2014 Oct; 171(19):4413-24; Mol Pharmacol. 2014 Sep; 86(3):330-41. References:
Molecular Weight (MW)	257.38
Formula	C17H23NO
CAS No.	489402-47-3
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 30 mg/mL
	Water:
	Ethanol:
Chemical Name	N-(2, 4, 6-trimethylphenyl)bicyclo[2.2.1]heptane-6-carboxamide
Synonyms	ML-213; ML 213; ML213; CID-3111211; CID 3111211; CID3111211
SMILES Code	O=C(C1CC2CCC1C2)NC3=C(C)C=C(C)C=C3C

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