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CYM-5541 (ML249)

CYM-5541 (ML249)

Item no.	V3237-10mg
Manufacturer	InvivoChem LLC
CASRN	945128-26-7
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3237CAS #:945128-26-7 Purity >=98% Description: CYM-5541 (also known as ML249) is a potent, selective, full, and allosteric agonist of the S1P3 (Sphingosine 1-phosphate) receptor with EC50 in the range of 72 to 132 nM. S1P is a lysophospholipid signaling molecule that regulates important biological functions, including lymphocyte trafficking and vascular development, by activating G protein-coupled receptors for S1P, namely, S1P(1) through S1P(5). CYM-5541 was used to to identify an allosteric site where Phe263 is a key gate-keeper residue for its affinity and efficacy. This ligand lacks a polar moiety, and the novel allosteric hydrophobic pocket permits S1P(3) selectivity of CYM-5541 within the highly similar S1P receptor family. Description: References: ACS Chem Biol. 2012 Dec 21; 7(12):1975-83. References:
Molecular Weight (MW)	316.45
Formula	C19H28N2O2
CAS No.	945128-26-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 40 mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	N, N-dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide
Synonyms	ML249; ML 249; ML-249; CYM-5541; CYM 5541; CYM5541
SMILES Code	O=C(C1=NOC(C2CC2)=C1)N(C3CCCCC3)C4CCCCC4

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Amount: 10 mg

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