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Description: Kira8 (AMG18) is a potent and mono-selective IRE1alpha kinase-inhibiting rnase attenuator (kira) inhibitor that allosterically attenuates IRE1alpha RNase activity with an IC50 of 5.9 nM. It can promote reversal of established fibrosis
References: TargetingABL-IRE1alpha Signaling Spares ER-Stressed Pancreatic beta Cells to ReverseAutoimmune Diabetes. Cell Metab. 2017 Apr 4; 25(4):883-897.e8.
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