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Erlotinib mesylate

Erlotinib mesylate

Item no.	V3252-5g
Manufacturer	InvivoChem LLC
CASRN	248594-19-6
Amount	5 g
Quantity options	10 g 1 g 2 g 500 mg 50 g
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3252CAS #:248594-19-6 (mesylate); 183319-69-9 (HCl); 183321-74-6 (free base)Purity >=98% Description: Erlotinib mesylate (also known as OSI-744 mesylate, trade name: Tarceva) is the mesylate salt of erlotinib which is an EGFR (epidermal growth factor receptor) inhibitor with IC50 of 2 nM in cell-free assays, and is > 1000-fold more sensitive for EGFR than human c-Src or v-Abl. Erlotinib is a quinazoline derivative with potent antineoplastic properties and has been approved for the treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. It acts by competing with adenosine triphosphate and reversibly binding to the intracellular catalytic domain of EGFR tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. Description: References: Cancer Res. 1997; 57(21):4838-48; Anticancer Drugs. 2004; 15(5):503-12; Mol Cancer Ther. 2008; 7(6):1708-19. References: Related CAS: 248594-19-6 (mesylate); 183319-69-9 (HCl); 183321-74-6 (free base) : 248594-19-6 (mesylate); 183319-69-9 (HCl)
Molecular Weight (MW)	393.44
Formula	C23H27N3O7S
CAS No.	248594-19-6 (mesylate); 183319-69-9 (HCl); 183321-74-6 (free base)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10mM
	Water: N/A
	Ethanol: N/A
SMILES Code	COCCOC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCOC.CS(=O)(O)=O
Synonyms	CP358774 mesylate; NSC 718781 mesylate; CP358774 mesylate, NSC 718781 mesylate; CP-358, 774 mesylate; CP-358774 mesylate; OSI-774 mesylate; OSI 774 mesylate; OSI774 mesylate; Erlotinib mesylate

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Amount: 5 g

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Delivery expected until 9/4/2025

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