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Cintirorgon (LYC-55716)

Cintirorgon (LYC-55716)

Item no.	V3253-2mg
Manufacturer	InvivoChem LLC
CASRN	2055536-64-4
Amount	2 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3253CAS #:2055536-64-4Purity >=98% Description: Cintirorgon (formerly also known as LYC55716), a novel and potent immune modulatory medicine developed by Lycera, is a synthetic and orally bioavailable small molecule agonist of RAR-related orphan receptor gamma (RORgamma). It combines multiple anti-tumor mechanisms into a single therapeutic by modulating gene expression to reprogram immune cells for improved function, as well as decrease immunosuppressive mechanisms. In January 2018, Lycera announced the initiation of a multi-center Phase 1B combination study in patients with advanced, relapsed, or refractory solid tumors such as metastatic Non-Small Cell Lung Cancer in combination with pembrolizumab. Description: References: 2018 ASCO-SITC Clinical Immuno-Oncology Symposium (Poster); Lycera Announces Initiation of Phase 1/2a Study ARGON of Immuno-Oncology Candidate LYC-55716 in Patients with Advanced Solid Tumors References: Related CAS #: 2055538-47-9 (sodium salt) 2055536-64-4 (free acid)
Molecular Weight (MW)	603.53
Formula	C??H??F?NO?S
CAS No.	2055536-64-4
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10mM
	Water: N/A
	Ethanol: N/A
Chemical Name	(S)-3-(6-(3-(difluoromethoxy)-5-fluorophenyl)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3, 4-dihydro-2H-benzo[b][1, 4]oxazin-2-yl)-2, 2-dimethylpropanoic acid
Synonyms	Cintirorgon; LYC-55716; LYC55716; LYC 55716
SMILES Code	O=C(O)C(C)(C)C[CH]1OC2=CC=C(C3=CC(F)=CC(OC(F)F)=C3)C=C2N(S(=O)(C4=CC=CC(C(F)(F)F)=C4)=O)C1

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Amount: 2 mg

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Delivery expected until 10/2/2025

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