N-deacetylated BMS-202

Description: N-deacetylated BMS-202, the deacetylated product of BMS-202 (also known as PD1-PDL1 inhibitor 2, BMS 202, BMS202), is a inhibitor of the PD-1 (Programmed death- 1)/PD-Ll (Programmed death-ligand 1) protein/protein interaction with potential anticancer activities. BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to various histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many system. Structural basis for blocking the PD-1/PD-L1 interaction by small molecules is illustrated with the compound BMS-202 that binds to and induces dimerization of PD-L1.

References: WO/2015034820 A1