BMS-8

Item no.	V3256-5mg
Manufacturer	InvivoChem LLC
CASRN	1675201-90-7
Amount	5 mg
Quantity options	100 mg 10 mg 1 mg 25 mg 2 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3256CAS #:1675201-90-7Purity >=98% Description: BMS-8 is an inhibitor of the PD-1 (Programmed death- 1)/PD-Ll (Programmed death-ligand 1) protein/protein interaction with potential anticancer activities. BMS-8 inhibits PD-1/PD-Ll interaction with IC50 of 146nM, and may augment therapeutic immune response to various histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many system. Structural basis for blocking the PD-1/PD-L1 interaction by small molecules is illustrated with the compound BMS-202 that binds to a hydrophobic cavity and induces dimerization of PD-L1. Description: References: J Med Chem. 2017 Jul 13; 60(13):5857-5867; Oncotarget. 2017 Aug 7; 8(42):72167-72181; WO/2015034820 A1 References:
Molecular Weight (MW)	494.43
Formula	C27H28BrNO3
CAS No.	1675201-90-7
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 20 mg/mL
	Water: N/A
	Ethanol: N/A
SMILES Code	O=C(C1N(CC2=CC=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C(Br)=C2)CCCC1)O
Chemical Name	1-[3-Bromo-4-(2-methyl-biphenyl-3-ylmethoxy)-benzyl]-piperidine-2-carboxylic acid
Synonym	BMS-8; BMS 8; BMS8

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Amount: 5 mg

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