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Mavorixafor (AMD-070) triHCl

Mavorixafor (AMD-070) triHCl

Item no.	V3259-10mg
Manufacturer	InvivoChem LLC
CASRN	880549-30-4
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3259CAS #:880549-30-4 (HCl); Purity >=98% Description: AMD-070 HCl (also known as AMD11070 HCl, AMD070, X4P-001 HCl and mavorixafor HCl) is a potent, selective and orally bioavailable antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, it inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs. The CXC chemokine receptor CXCR2 is upregulated in a variety of different tumor cell types and involved in tumor cell proliferation and progression. Inhibition of CXCR2 led to reduced metastasis and decreased tumorigenesis. As a CXCR2 antagonist, SX-682 has the potential to treat cancer. AMD-070 has been evaluated in phase I/II studies in different solid tumors by X4 Pharmaceuticals. This compound also has the potential use for the treatment of HIV-1 infection. Description: References: PLoS One. 2016 Mar 21; 11(3):e0151765; J Med Chem. 2010 Apr 22; 53(8):3376-88. References: Related CAS?558447-26-0 (free base)
Molecular Weight (MW)	458.86
Formula	C21H30Cl3N5
CAS No.	880549-30-4 (HCl)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 10 mM
	Water:
	Ethanol:
Chemical Name	(S)-N1-((1H-benzo[d]imidazol-2-yl)methyl)-N1-(5, 6, 7, 8-tetrahydroquinolin-8-yl)butane-1, 4-diamine trihydrochloride
Synonyms	X4P-001 3HCl; X4P 0013HCl; X4P001 3HCl; AMD11070 3HCl; AMD-11070 3HCl; AMD 11070 3HCl; AMD-070 3HCl; AMD 070 3HCl; AMD070 3HCl; mavorixafor 3HCl
SMILES Code	NCCCCN(CC1=NC2=CC=CC=C2N1)[CH]3CCCC4=C3N=CC=C4.[H]Cl.[H]Cl.[H]Cl

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Amount: 10 mg

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