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dcc-2618

dcc-2618

Item no.	V3284-10mg
Manufacturer	InvivoChem LLC
CASRN	1442472-39-0
Amount	10 mg
Quantity options	100 mg 1 g 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3284CAS #:1442472-39-0; DCC-2618 HClPurity >=98% Description: DCC-2618 (Ripretinib) is a potent, orally bioactive, and spectrum-selective pan KIT and PDGFRA inhibitor which blocks KIT D816V and multiple other kinase targets relevant to systemic mastocytosis. DCC-2618 inhibits the proliferation and survival of various human mast cell lines (e.g. HMC-1, ROSA, MCPV-1) as well as primary neoplastic mast cells obtained from patients with advanced systemic mastocytosis (IC50< 1 uM). Moreover, DCC-2618 decreased growth and survival of primary neoplastic eosinophils obtained from patients with systemic mastocytosis or eosinophilic leukemia, leukemic monocytes obtained from patients with chronic myelomonocytic leukemia with or without concomitant systemic mastocytosis, and blast cells obtained from patients with acute myeloid leukemia. DCC-2618 is effective in vivo in patients with advanced systemic mastocytosis and is currently under investigation in clinical trials. Description References: Haematologica. 2018 May; 103(5):799-809; Cancer Discov. 2017 Feb; 7(2):121-122. References:
Molecular Weight (MW)	510.37
Formula	C24H21BrFN5O2
CAS No.	1442472-39-0; 1225278-16-9 (wrong)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 100 mg/mL
	Water: < 1 mg/mL
	Ethanol: 10 mg/mL
Chemical Name	1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1, 2-dihydro-1, 6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
Synonyms	DCC-2618; DCC 2618; DCC2618; Ripretinib
SMILES Code	O=C(NC1=CC(C2=CC3=C(C=C(NC)N=C3)N(CC)C2=O)=C(Br)C=C1F)NC4=CC=CC=C4

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Amount: 10 mg

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Delivery expected until 9/4/2025

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