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Rosuvastatin

Rosuvastatin

Item no.	V3294-25mg
Manufacturer	InvivoChem LLC
CASRN	287714-41-4
Amount	25 mg
Quantity options	100 mg 10 mg 250 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3294CAS #:287714-41-4 (free acid); N/A (Rosuvastatin D6 Calcium); N/A ( Rosuvastatin D6 Sodium); 1279031-70-7 (Rosuvastatin D3 Sodium); 147098-20-2 (Rosuvastatin calcium)Purity >=98% Description: Rosuvastatin (also known as S-4522 and ZD 4522, trade name: Crestor) is a member of the statin class of drugs and a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM in a cell-free assay. Rosuvastatin belongs to the statin class that is used for the treatment of high cholesterol and related conditions such as dyslipidemia, and to prevent cardiovascular disease. Its approximate elimination half life is 19 h and its time to peak plasma concentration is reached in 3–5 h following oral administration. In 2013 Crestor was the fourth-highest selling drug in the United States, accounting for approx. $5.2 billion in sales. Description: References: Clin Pharmacol Ther. 2004 May; 75(5):455-63; Bioorg Med Chem. 1997 Feb; 5(2):437-44. References:
Molecular Weight (MW)	481.54
Formula	C22H28FN3O6S
CAS No.	287714-41-4 (free acid); 147098-20-2 (calcium)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 100 mg/mL (199.8 mM)
	Water: < 1 mg/mL
	Ethanol: < 1 mg/mL
Solubility (In vivo)	4% DMSO+30% PEG 300+dd H2O: 10 mg/mL
Synonyms	ZD 4522; ZD-4522; ZD4522; S-4522; S 4522; S4522; Brand name: Crestor.
Chemical Name	(3R, 5S, E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3, 5-dihydroxyhept-6-enoate
SMILES Code	O=C(O)C[CH](O)C[CH](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2

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Amount: 25 mg

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Delivery expected until 10/2/2025

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