RO-3

Item no.	V3327-50mg
Manufacturer	InvivoChem LLC
CASRN	1026582-88-6
Amount	50 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 500 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3327CAS #:1026582-88-6 Purity >=98% Description: RO-3 is potent, selective, orally active and brain penetrant antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor with pIC50 values are 7.0 and 5.9 respectively. It exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 uM). It attenuates nociceptive sensitivity in animal models of pain. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and P2X(7), and P2Y (e.g., P2Y(2)) receptors, can modulate pain Description: References: Br J Pharmacol. 2006 Feb; 147 Suppl 2:S132-43; J Pharmacol Exp Ther. 2008 Feb; 324(2):409-15. References:
Molecular Weight (MW)	302.38
Formula	C16H22N4O2
CAS No.	1026582-88-6
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: 10 mM
	Water: N/A
	Ethanol: N/A
Chemical Name	5-(2-isopropyl-4, 5-dimethoxybenzyl)pyrimidine-2, 4-diamine
Synonyms	RO-3; RO 3; RO3
SMILES Code	NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C(C)C)C(N)=N1

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Amount: 50 mg

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