(RS)-MCPG

Description: (RS)-a-Methyl-4-carboxyphenylglycine (RS)-MCPG is a group I and II mGluR (metabotropic glutamate receptor) antagonist, it blocked TBS-induced shifts in both juvenile and neonatal hippocampal neurons. While blockade of mGluR1 or mGluR5 alone could interfere with TBS-induced shifts in EGABA in neonates, only a combined blockade could do the same in juveniles. These results indicate that TBS induces a negative shift in EGABA in juvenile hippocampal neurons but a positive shift in neonatal hippocampal neurons via corresponding changes in KCC2 and NKCC1 expressions, respectively. mGluR activation seems to be necessary for both shifts to occur while the specific receptor subtype involved seems to vary.

References: PLoS One. 2015 Sep 21; 10(9):e0138215.