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Pimavanserin tartrate

Pimavanserin tartrate

Item no.	V3350-1g
Manufacturer	InvivoChem LLC
CASRN	706782-28-7
Amount	1 g
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3350CAS #:706782-28-7 (tartrate); 706779-91-1 (free base)Purity >=98% Description: Pimavanserin (also known as ACP-103) is a novel, potent, efficacious, orally active and selective inverse agonist of the 5-HT2A (serotonin receptor subtype 2A) receptor with pIC50 and pKd of 8.73 and 9.3, respectively. ACP-103 reduced tacrine-induced tremulous jaw movements in rats. In addition, ACP-103 administered in combination with levodopa caused a dose-related reduction in dyskinesias in monkeys. These data suggest that ACP-103 may have the potential to reduce tremor and levodopa-induced dyskinesias in Parkinson's disease. Description: References: Pharmacol Biochem Behav. 2008 Oct; 90(4):540-4; J Pharmacol Exp Ther. 2006 May; 317(2):910-8. References:
Molecular Weight (MW)	1005.21
Formula	C54H74F2N6O10
CAS No.	706782-28-7 (tartrate)
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: >= 70mg/mL
	Water: N/A
	Ethanol: N/A
Chemical Name	1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidin-4-yl)urea hemi((2R, 3R)-2, 3-dihydroxysuccinate)
Synonyms	ACP-103 tartrate; ACP 103; ACP103; Trade name: Nuplazid
SMILES Code	O=C(NCC1=CC=C(OCC(C)C)C=C1)N(CC2=CC=C(F)C=C2)C3CCN(C)CC3.O=C(O)[CH](O)[CH](O)C(O)=O.O=C(NCC4=CC=C(OCC(C)C)C=C4)N(CC5=CC=C(F)C=C5)C6CCN(C)CC6

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Amount: 1 g

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