CHZ868

Item no.	V3373-500mg
Manufacturer	InvivoChem LLC
CASRN	1895895-38-1
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3373CAS #:1895895-38-1Purity >=98% Description: CHZ868 is a novel, potent and selective type II JAK2 inhibitor with an IC50 of 0.17 uM in EPOR JAK2 WT Ba/F3 cell. It stabilizes JAK2 in an inactive conformation. CHZ868 potently suppressed the growth of CRLF2-rearranged human B-ALL cells, abrogated JAK2 signaling, and improved survival in mice with human or murine B-ALL. CHZ868 and dexamethasone synergistically induced apoptosis in JAK2-dependent B-ALLs and further improved in vivo survival compared to CHZ868 alone. These data support the testing of type II JAK2 inhibition in patients with JAK2-dependent leukemias and other disorders. Description: References: Cancer Cell. 2015 Jul 13; 28(1):29-41; Cancer Cell. 2015 Jul 13; 28(1):15-28. References:
	Name: CHZ868 CAS#: 1895895-38-1 Chemical Formula: C22H19F2N5O2 Exact Mass: 423.15068 Molecular Weight: 423.42 Elemental Analysis: C, 62.41; H, 4.52; F, 8.97; N, 16.54; O, 7.56
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: CHZ868; CHZ 868; CHZ-868 Chemical Name: N-(4-((2-((2, 4-difluorophenyl)amino)-1, 4-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)pyridin-2-yl)acetamide InChi Key: KQQLBXFPTDVFAJ-UHFFFAOYSA-N InChi Code: InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H, 1-3H3, (H, 27, 28)(H, 25, 26, 30) SMILES Code: CC(NC1=NC=CC(OC2=CC=C3N(C)C(NC4=CC=C(F)C=C4F)=NC3=C2C)=C1)=O

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 500 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 14 days

Compare

Add to wishlist

Get an offer