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PF-9366

PF-9366

Item no.	V3386-10mg
Manufacturer	InvivoChem LLC
CASRN	72882-78-1
Amount	10 mg
Quantity options	100 mg 250 mg 25 mg 500 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3386CAS #:72882-78-1 Purity >=98% Description: PF-9366 is a novel, potent and allosteric inhibitor of human methionine adenosyltransferase 2A (Mat2A) with an IC50 of 420 nM and a Kd of 170 nM. Human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform, is often deregulated in cancer. We identified a Mat2A inhibitor, PF-9366, binds an allosteric site on Mat2A that overlaps with the binding site for the Mat2A regulator, Mat2B. Studies exploiting PF-9366 suggested a general mode of Mat2A allosteric regulation. Allosteric binding of PF-9366 or Mat2B altered the Mat2A active site, resulting in increased substrate affinity and decreased enzyme turnover. These data support a model whereby Mat2B functions as an inhibitor of Mat2A activity when methionine or SAM levels are high, yet functions as an activator of Mat2A when methionine or SAM levels are low. References: Nat Chem Biol. 2017 Jul; 13(7):785-792.
	Name: PF-9366 CAS#: 72882-78-1 Chemical Formula: C20H19ClN4 Exact Mass: 350.1298 Molecular Weight: 350.85 Elemental Analysis: C, 68.47; H, 5.46; Cl, 10.10; N, 15.97
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: PF-9366; PF 9366; PF9366. Chemical Name: 2-(7-Chloro-5-phenyl-[1, 2, 4]triazolo[4, 3-a]quinolin-1-yl)-N, N-dimethylethan-1-amine InChi Key: LYLASWLQCMKZAT-UHFFFAOYSA-N InChi Code: InChI=1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9, 12-13H, 10-11H2, 1-2H3 SMILES Code: CN(C)CCC1=NN=C2N1C3=C(C=C(Cl)C=C3)C(C4=CC=CC=C4)=C2

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Amount: 10 mg

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Delivery expected until 9/4/2025

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