Tunicamycin

Description: Tunicamycin, a mixture of homologous nucleosides, is a N-acetylglucosamine containing antibiotic found in Streptomyces lysosuperijkus which inhibits protein glycosylation. Tunicamycin causes accumulation of unfolded proteins in cell endoplasmicreticulum (ER) and induces ER stress, and causes blocking of DNAsynthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.

References: Nami B et al. Tunicamycin-induced endoplasmic reticulum stress reduces in vitro subpopulation and invasion of CD44+/CD24- phenotype breast cancer stem cells. Exp Toxicol Pathol. 2016 Aug; 68(7):419-26.2. Guo Q et al. Tunicamycin Aggravates Endoplasmic Reticulum Stress and Airway Inflammation via PERK-ATF4-CHOP Signaling in a Murine Model of Neutrophilic Asthma. J Asthma. 2016 Jul 6