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TCS 401

TCS 401

Item no.	V3399-250mg
Manufacturer	InvivoChem LLC
CASRN	243966-09-8
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3399CAS #:243966-09-8 (HCI salt); 243967-42-2 (free base) Purity >=98% Description: TCS-401 HCI is a novel, potent and selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) with Ki of 0.29 uM. PTP1B was expressed in the RPE layer of the normal retina. After retinal detachment, weak immunolabeling of PTP1B was seen in the RPE cells. TCS-401 promoted the proliferation and expression of cyclin A and cyclin D1 in RPE cells. TCS-401 induced RPE cells to differentiate toward better contractility and motility. A migration assay proved that inhibiting PTP1B improved the migratory activity of RPE cells. TCS-401 activated extracellular signal-regulated kinase (Erk) and protein kinase B (Akt) phosphorylation. Pretreatment with PD98059 and LY294002 abolished TCS-401-induced activation of Erk, Akt, cell proliferation, and cell migration. References: Mol Vis. 2015 May 1; 21:523-31. eCollection 2015; Am J Physiol Renal Physiol. 2013 Mar 15; 304(6):F698-709.
	Name: TCS-401 HCI salt CAS#: 243966-09-8 Chemical Formula: C10H11ClN2O5S Exact Mass: 306.0077 Molecular Weight: 306.72 Elemental Analysis: C, 39.16; H, 3.62; Cl, 11.56; N, 9.13; O, 26.08; S, 10.45
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: TCS-401 (HCI), TCS 401 (HCI), TCS401 (HCI), TCS-401 Hydrochloride Chemical Name: 2-(Oxaloamino)-4, 5, 6, 7-tetrahydrothieno[2, 3-c]pyridine-3-carboxylic acid hydrochloride InChi Key: LQGCAMWQDSYOAY-UHFFFAOYSA-N InChi Code: InChI=1S/C10H10N2O5S.ClH/c13-7(10(16)17)12-8-6(9(14)15)4-1-2-11-3-5(4)18-8; /h11H, 1-3H2, (H, 12, 13)(H, 14, 15)(H, 16, 17); 1H SMILES Code: O=C(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)O.[H]Cl

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 250 mg

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Delivery expected until 9/4/2025

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