Y-39983

Description: Y-39983 (also called Y-33075) is a novel, potent and selective inhibitor of Rho-associated coiled coil-forming protein kinase( ROCK ) with IC50 values of 3.6 nM, 0.42 uM and 0.81 uM for ROCK, PKC and CaMKII, respectively. Y-39983 acts by downregulating RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Y-39983 also promotes regeneration of crushed axons of retinal ganglion cells into the optic nerve of adult cats. Y-39983 has been reported to relax the ciliary arteries of precontracted isolated rabbit in vitro. In addition, Y-39983 has been found to increase optic-nerve-head blood flow by laser speckle flowmetry. Moreover, Y-39983 lowered the intraocular pressure ( IOP) in a dose-dependent fashion in the eyes of rabbits and monkeys.

References: Ophthalmol. Vis. Sci. 2007, 48 (7), 3216-3222; Curr Eye Res. 2011 Oct; 36(10):964-70; Jpn J Ophthalmol. 2011 Jul; 55(4):411-417; Nature. 1997 Oct 30; 389(6654):990-4; Nat Med. 1999 Feb; 5(2):221-5.

Related CAS#: 199433-58-4 (free base); 173897-44-4 (2HCl) 471843-75-1