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Description: Brassinolide, a plant growth modulator and a plant hormone, is a sterol compound first isolated from pollen of rape (Brassica napus L.). It could promote stem elongation and cell division. In addition, brassinolide has potential anticancer activities. It could induce a time and concentration-dependent cytotoxicity in PC-3 cells. The mode of cell death appeared to be predominately apoptosis. Brassinolide treatment can increase Caspase-3 activity. Western blot studies indicated that treatment with brassinolide triggered a time-dependent decrease in the expression of anti-apoptotic protein Bcl-2. Therefore, brassinolide could induce cytotoxicity in PC-3 cells by triggering apoptosis. Brassinolide might therefore be a promising candidate for the treatment of prostate cancer.
References: Pharmazie. 2007 May; 62(5):392-5; Yao Xue Xue Bao. 2005 Feb; 40(2):117-21.
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