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PF-670462

PF-670462

Item no.	V3427-500mg
Manufacturer	InvivoChem LLC
CASRN	950912-80-8
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3427CAS #:950912-80-8Purity >=98% Description: PF-670462 (also known as PF670) is a novel, potent and selective inhibitor of casein kinase (CK1epsilon and CK1delta), with IC50s of 7.7 nM and 14 nM, respectively. Casein kinase 1 delta and epsilon (CK1delta/?) are key regulators of diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. Recent studies suggest that they have an important role in oncogenesis. RNA interference screens identified CK1? as a pro-survival factor in cancer cells in vitro and the CK1delta/?-specific inhibitor IC261 is remarkably effective at selective, synthetic lethal killing of cancer cells. References: J Pharmacol Exp Ther. 2007 Aug; 322(2):730-8; Oncogene. 2011 Jun 2; 30(22):2558-69; Mol Cell Biochem. 2015 Jan; 398(1-2):195-206.
	Name: PF-670462 di-HCl CAS#: 950912-80-8 Chemical Formula: C19H22Cl2FN5 Exact Mass: 337.1703 Molecular Weight: 410.3184 Elemental Analysis: C, 55.62; H, 5.40; Cl, 17.28; F, 4.63; N, 17.07
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: PF-670; PF670; PF 670; PF-670462 HCl; PF-670462 hydrochloride; PF-670462; PF 670462; PF670462. Chemical Name: 4-[1-Cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride InChi Key: PSNKGVAXBSAHCH-UHFFFAOYSA-N InChi Code: InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15; ; /h6-12, 15H, 1-5H2, (H2, 21, 22, 24); 2*1H SMILES Code: NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.[H]Cl.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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Delivery expected until 9/4/2025

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