Ezatiostat

InvivoChem Cat #:V3435CAS #:168682-53-9Purity >=98%

Description: Ezatiostat (formerly known as TER199; TLK199; Brand name: Telentra) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1). It was shown that an ezatiostat response profile contains two miRNAs that regulate expression of genes known to be implicated in MDS disease pathology. Remarkably, pathway analysis of the response profile revealed that the genes comprising the jun-N-terminal kinase/c-Jun molecular pathway, which is known to be activated by ezatiostat, are under-expressed in patients who respond and over-expressed in patients who were non-responders to the drug, suggesting that both the biology of the disease and the molecular mechanism of action of the drug are positively correlated.

References: J Hematol Oncol. 2012 May 6; 5:20.

-20C for 3 years in powder form

Synonym: TLK199; TLK-199; TLK 199; Ezatiostat; TER-199; TLK-199 hydrochloride; TER 199; TLK 199 hydrochloride; TER199; TLK199 hydrochloride; trade name: Telintra
Chemical Name: (S)-ethyl 2-amino-5-(((R)-3-(benzylthio)-1-(((S)-2-ethoxy-2-oxo-1-phenylethyl)amino)-1-oxopropan-2-yl)amino)-5-oxopentanoate
InChi Key: GWEJFLVSOGNLSS-FIXSFTCYSA-N
InChi Code: InChI=1S/C27H35N3O6S/c1-3-35-26(33)21(28)15-16-23(31)29-22(18-37-17-19-11-7-5-8-12-19)25(32)30-24(27(34)36-4-2)20-13-9-6-10-14-20/h5-14, 21-22, 24H, 3-4, 15-18, 28H2, 1-2H3, (H, 29, 31)(H, 30, 32)/t21-, 22-, 24-/m0/s1
SMILES Code: O=C(OCC)[CH](N)CCC(N[CH](CSCC1=CC=CC=C1)C(N[CH](C2=CC=CC=C2)C(OCC)=O)=O)=O