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Description: UNC0321 is a novel, potent and selective G9a histone methyltransferase inhibitor with Ki of 63 pM, UNC0321 was discovered by optimizing the 7-dimethylaminopropoxy side chain on the basis of the structural insights revealed by UNC0224-G9a cocrystal structure. UNC0321 is the first G9a inhibitor with picomolar potency.
References: J Med Chem. 2011 Sep 8; 54(17):6139-50; J Med Chem. 2010 Aug 12; 53(15):5844-57. d
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