BMS-509744

InvivoChem Cat #:V3466CAS #:439575-02-7Purity >=98%

Description: BMS-509744 is a novel, potent and selective inhibitor of interleukin-2 inducible T cell kinase (ITK) with IC50 of 19 nM. It displays 200-fold selectivity over Tec family kinases and 55-fold selectivity over other kinases tested. BMS-509744 reduces HIV infection of primary CD4+ T cells and attenuates the establishment of HIV infection in vitro. BMS-509744 also reduces T cell proliferation and IL-2 production in vitro.

References: Biochemistry. 2004 Aug 31; 43(34):11056-62.

-20C for 3 years in powder form

Synonym: BMS-509744; BMS 509744; BMS509744; CHEMBL209148.
Chemical Name: Benzamide, N-(5-((5-((4-acetyl-1-piperazinyl)carbonyl)-4-methoxy-2-methylphenyl)thio)-2-thiazolyl)-4-(((1, 2, 2-trimethylpropyl)amino)methyl)-
InChi Key: ZHXNIYGJAOPMSO-UHFFFAOYSA-N
InChi Code: InChI=1S/C32H41N5O4S2/c1-20-16-26(41-7)25(30(40)37-14-12-36(13-15-37)22(3)38)17-27(20)42-28-19-34-31(43-28)35-29(39)24-10-8-23(9-11-24)18-33-21(2)32(4, 5)6/h8-11, 16-17, 19, 21, 33H, 12-15, 18H2, 1-7H3, (H, 34, 35, 39)
SMILES Code: Cc1cc(c(cc1Sc2cnc(s2)NC(=O)c3ccc(cc3)CNC(C)C(C)(C)C)C(=O)N4CCN(CC4)C(=O)C)OC