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Adagrasib (MRTX849)

Adagrasib (MRTX849)

Item no.	V34672-500mg
Manufacturer	InvivoChem LLC
CASRN	2326521-71-3
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V34672CAS #:2326521-71-3Purity >=98% Description: Adagrasib (MRTX-849) is a novel, potent, selective, orally bioavailable and covalent / irreversible inhibitor of KRAS G12C with IC50s ranging between 10 and 973 nM in the 2D format and between 0.2 and 1042 nM in the 3D format. It has potential antineoplastic activity and acts by covalently binding to KRAS G12C at the cysteine at residue 12, locking the protein in its inactive GDP-bound conformation, and inhibiting KRAS-dependent signal transduction. References: 1. Christensen JG, et al. The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients. Cancer Discov. 2019 Oct 28. pii: CD-19-1167. 2. Kyriakos P. Papadopoulos, et al. A phase I/II multiple expansion cohort trial of MRTX849 in patients with advanced solid tumors with KRAS G12C mutation. Journal of Clinical Oncology 2019 37:15_suppl, TPS3161-TPS3161.

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Amount: 500 mg

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Delivery expected until 9/4/2025

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