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BMS-816336

BMS-816336

Item no.	V3491-250mg
Manufacturer	InvivoChem LLC
CASRN	1009583-20-3
Amount	250 mg
Quantity options	100 mg 10 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3491CAS #:1009583-20-3; 1009365-98-3 Purity >=98% Description: BMS-816336 is a potent and orally bioactive inhibitor of human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme with an IC50 of 3.0 nM. BMS-816336 showed activity against human 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme (IC50 3.0 nM) with > 10000 fold selectivity over human 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2). BMS-816336 exhibits a robust acute pharmacodynamic effects in cynomolgus monkeys (ED50 0.13 mpk) and in DIO mice. BMS-816336 was found to be well-tolerated in Phase 1 clinical studies and represents a potential new treatment for type 2 diabetes, metabolic syndrome, and other human diseases modulated by glucocorticoid control. References: J Med Chem. 2017 Jun 22; 60(12):4932-4948.
	Name: BMS-816336 CAS#: 1009583-20-3 Chemical Formula: C21H27NO3 Exact Mass: 341.1991 Molecular Weight: 341.451 Elemental Analysis: C, 73.87; H, 7.97; N, 4.10; O, 14.06
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: BMS-816336; BMS 816336; BMS816336. Chemical Name: 2-((1R, 2R, 3S, 5R, 6R)-6-hydroxy-2-phenyladamantan-2-yl)-1-(3-hydroxyazetidin-1-yl)ethan-1-one InChi Key: OAAZMUGLOXGVNH-MEMOLBONSA-N, OAAZMUGLOXGVNH-CCVYDFRESA-N InChi Code: InChI=1S/C21H27NO3/c23-18-11-22(12-18)19(24)10-21(15-4-2-1-3-5-15)16-6-13-7-17(21)9-14(8-16)20(13)25/h1-5, 13-14, 16-18, 20, 23, 25H, 6-12H2/t13-, 14?, 16-, 17+, 20-, 21-/m1/s1 SMILES Code: OC1CN(C(C[C]2(C3=CC=CC=C3)[CH]4C[CH]5[CH](O)C(C4)C[CH]2C5)=O)C1

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Amount: 250 mg

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Delivery expected until 11/6/2025

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