fosravuconazole

InvivoChem Cat #:V3507CAS #:351227-64-0 (Fosravuconazole); 914361-44-7 (Fosravuconazole monolysine); 914361-45-8 (Fosravuconazole L-lysine ethanolate)Purity >=98%

Description: Fosravuconazole (formerly known as E-1224, BEF-1224, and BMS-379224) is an azole antifungal agent that can be potentially used for the treatment of fungal infections. Fosravuconazole is a prodrug of ravuconazole with improved water solubility. The phosphonooxymethyl ether fosravuconazole was prepared from ravuconazole and bis-tert-butyl chloromethylphosphate. Fosravuconazole was highly soluble in water and converted to the parent in alkaline phosphatase, and also in vivo (rat). Fosravuconazole has proved to be one of the most promising prodrugs of ravuconazole that were tested, and it is currently in clinical evaluation as an intravenous formulation of the broad spectrum antifungal azole, ravuconazole.

References: Bioorg Med Chem Lett. 2003 Nov 3; 13(21):3669-72.

-20C for 3 years in powder form

Synonym: Fosravuconazole; BEF-1224; BEF1224; BEF 1224; BMS-379224; BMS379224; BMS 379224; E-1224; E 1224; E1224.
Chemical Name: (((2R, 3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2, 4-difluorophenyl)-1-(1H-1, 2, 4-triazol-1-yl)butan-2-yl)oxy)methyl dihydrogen phosphate
InChi Key: SYTNEMZCCLUTNX-NPMXOYFQSA-N
InChi Code: InChI=1S/C23H20F2N5O5PS/c1-15(22-29-21(10-37-22)17-4-2-16(9-26)3-5-17)23(11-30-13-27-12-28-30, 34-14-35-36(31, 32)33)19-7-6-18(24)8-20(19)25/h2-8, 10, 12-13, 15H, 11, 14H2, 1H3, (H2, 31, 32, 33)/t15-, 23+/m0/s1
SMILES Code: N#CC1=CC=C(C2=CSC([CH](C)[C](OCOP(O)(O)=O)(C3=CC=C(F)C=C3F)CN4N=CN=C4)=N2)C=C1