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GSK3179106

GSK3179106

Item no.	V3552-500mg
Manufacturer	InvivoChem LLC
CASRN	1627856-64-7
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3552CAS #:1627856-64-7 Purity >=98% Description: GSK3179106 is a novel, potent, selective, and gut-restricted RET kinase inhibitor with an IC50 of 0.4 nM. In all the rat models, RET inhibition with GSK3179106 attenuated the number of abdominal contractions induced by CRD. Our findings identify a role for RET in visceral nociception. Inhibition of RET kinase with a potent, selective, and gut-restricted small molecule may represent a novel therapeutic strategy for the treatment of IBS through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity. References: Neurogastroenterol Motil. 2018 Oct 12:e13479.; J Pharmacol Exp Ther. 2019 Feb; 368(2):299-307. Related CAS#:1884420-19-2 (GSK3179106 hydrate)
	Name: GSK3179106 CAS#: 1627856-64-7 Chemical Formula: C22H21F4N3O4 Exact Mass: 467.1468 Molecular Weight: 467.4206 Elemental Analysis: C, 56.53; H, 4.53; F, 16.26; N, 8.99; O, 13.69
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GSK3179106; GSK-3179106; GSK 3179106. Chemical Name: 2-(4-(4-ethoxy-6-oxo-1, 6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(5-(1, 1, 1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)acetamide InChi Key: IDXKJSSOUXWLDB-UHFFFAOYSA-N InChi Code: InChI=1S/C22H21F4N3O4/c1-4-32-16-9-19(30)27-11-14(16)12-5-6-13(15(23)7-12)8-20(31)28-18-10-17(33-29-18)21(2, 3)22(24, 25)26/h5-7, 9-11H, 4, 8H2, 1-3H3, (H, 27, 30)(H, 28, 29, 31) SMILES Code: O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)CC2=CC=C(C(C(OCC)=C3)=CNC3=O)C=C2F

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Amount: 500 mg

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Delivery expected until 10/2/2025

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