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Rimonabant HCl (SR141716)

Rimonabant HCl (SR141716)

Item no.	V3565-100mg
Manufacturer	InvivoChem LLC
CASRN	158681-13-1
Amount	100 mg
Quantity options	10 mg 1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3565CAS #:158681-13-1Purity >=98% Description: Rimonabant (also known as SR141716, SR 141716A; A 281) is a novel, potent and selective antagonist (inverse agonist) of cannabinoid CB1 receptor with IC50 of 13.6 nM and EC50 of 17.3 nM in hCB1 transfected HEK 293 membrane. Rimonabant is used as an anorectic anti-obesity drug. Its main effect is the reduction of appetite. Rimonabant has shown a 285–fold CB1 selectivity (Ki=1.8nM CB1, 514nM CB2). The affinity of Rimonabant for CB1-Rs is 50-fold higher than for CB2-Rs with a Ki value of 6.18nM for CB1-Rs. In addition, Rimonabant has been revealed to produce changes in ingestive behaviors when treatment alone. Description: References: FEBS Lett. 1994 Aug 22; 350(2-3):240-4; Int J Cancer. 2009 Sep 1; 125(5):996-1003. References: Related CAS#:158681-13-1 (HCl); 168273-06-1 (free base)
Molecular Weight (MW)	500.25
Formula	C22H22Cl4N4O
CAS No.	158681-13-1 (HCl);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 30 mg/mL
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 30 mg/mL
Synonyms	SR141716 HCl; SR-141716; SR 141716; SR-141716; A 281; A-281; A281; SR 141716A; SR 151716A; SR-141716A; SR-151716A; SR141716A; SR151716A; Rimonabant, Acomplia, Zimulti

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Amount: 100 mg

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