« Back
Home /
GSK656 HCl (GSK3036656, GSK070)

GSK656 HCl (GSK3036656, GSK070)

Item no.	V3594-100mg
Manufacturer	InvivoChem LLC
CASRN	2131798-13-3
Amount	100 mg
Quantity options	10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3594CAS #:2131798-13-3Purity >=98% Description: GSK656 (GSK-3036656 and GSK-070) is a novel and potent antitubercular agent which acts as an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS), with an IC50 of 0.2 uM. There is an urgent need to develop new and safer antitubercular agents that possess a novel mode of action. GSK3036656 (abbreviated as GSK656) shows potent inhibition of Mtb LeuRS (IC50 = 0.20 uM) and in vitro antitubercular activity (Mtb H37Rv MIC = 0.08 uM). Additionally, it is highly selective for the Mtb LeuRS enzyme with IC50 of > 300 uM and 132 uM for human mitochondrial LeuRS and human cytoplasmic LeuRS, respectively. In addition, it exhibits remarkable PK profiles and efficacy against Mtb in mouse TB infection models with superior tolerability over initial leads. This compound has been progressed to clinical development for the treatment of tuberculosis. References: J Med Chem. 2017 Oct 12; 60(19):8011-8026. Related CAS #: 2131798-12-2 (free base); 2131798-13-3 (HCl)
	Name: GSK656 HCl CAS#: 2131798-13-3 (HCl); 2131798-12-2 (free base); Chemical Formula: C10H14BCl2NO4 Exact Mass: Molecular Weight: 293.935 Elemental Analysis: C, 40.86; H, 4.80; B, 3.68; Cl, 24.12; N, 4.77; O, 21.77
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: GSK3036656; GSK-3036656; GSK 3036656; GSK070; GSK-070; GSK 070; GSK656; GSK-656; GSK 656; GSK656 HCl. GSK656 hydrochloride Chemical Name: (S)?3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1, 2]oxaborol-1(3H)?ol hydrochloride SMILES Code: OB1O[CH](CN)C2=C(Cl)C=CC(OCCO)=C12.[H]Cl

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

Request safety datasheet

Simple Order Order Subscription

Amount: 100 mg

available

Delivery expected until 10/2/2025

Express Delivery: Save 27 days

Compare

Add to wishlist

Get an offer