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Dabrafenib mesylate

Dabrafenib mesylate

Item no.	V3634-100mg
Manufacturer	InvivoChem LLC
CASRN	1195768-06-9
Amount	100 mg
Quantity options	1 g 250 mg 25 mg 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3634CAS #:1195768-06-9Purity >=98% Description: Dabrafenib mesylate (formerly known as GSK2118436 mesylate) is a novel, specific, orally bioavailable inhibitor of BRAF V600 mutants with IC50 of 0.8 nM in cell-free assays and is 4- and 6-fold less potent against B-Raf (wildype) and c-Raf, respectively. It potently inhibits BRAFV600E, BRAFV600K and BRAFV600D with IC50 values of 0.5nM, 0.6nM and 1.9nM, respectively. Dabrafenib is currently approved by FDA and is widely used in cancer patients harboring BRAF mutations. It is reported that treatment of dabrafenib shrinks the overall size of brain metastases in patients. FDA approved Dabrafenib in 2013 to treat melanoma. References: Arch Pharm Res. 2011 May; 34(5):699-701. Related CAS#:1195765-45-7 (free base)
Molecular Weight (MW)	615.66
Formula	C24H24F3N5O5S3
CAS No.	1195768-06-9 (mesylate);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: > 30 mg/mL (57.74 mM)
	Water: N/A
	Ethanol: N/A
Solubility (In vivo)	30% PEG400+0.5% Tween80+5% Propylene glycol: 8 mg/mL
Synonyms	GSK2118436A Mesylate; GSK 2118436A Mesylate; GSK-2118436A; GSK2118436B ( Dabrafenib Mesylate); GSK-2118436B Mesylate; GSK 2118436B. Trade name: Tafinlar.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 mg

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Delivery expected until 10/2/2025

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