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Adezmapimod (SB-203580) hydrochloride

Adezmapimod (SB-203580) hydrochloride

Item no.	V3639-1g
Manufacturer	InvivoChem LLC
CASRN	869185-85-3
Amount	1 g
Quantity options	100 mg 10 mg 250 mg 25 mg 2 g 500 mg 50 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3639CAS #:869185-85-3 Purity >=98% Description: SB203580 (also known as RWJ 64809) is a novel and potent p38 mitogen-activated protein kinase inhibitor (p38MAPK inhibitor) with IC50 of 0.3-0.5 uM in THP-1 cells, it is 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 uM. SB203580 suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model. SB203580 is a competitive ATPsite inhibitor of p38MAPK with a selectivity probably determined by nonconserved regions within or near the ATP binding pocket and a Ki of 21 nM. References: J Biol Chem. 2000 Mar 10; 275(10):7395-402; Br J Pharmacol. 2000 Sep; 131(1):99-107. Related CAS#: 152121-47-6 (free base)
Molecular Weight (MW)	413.90
Formula	C??H??ClFN?OS
CAS No.	869185-85-3 (hydrochloride salt);
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Solubility (In vitro)	DMSO: N/A
	Water: > 8mg/mL
	Ethanol: N/A
SMILES	O=S(C1=CC=C(C2=NC(C3=CC=C(F)C=C3)=C(C4=CC=NC=C4)N2)C=C1)C.[H]Cl
Synonyms	RWJ 64809; PB 203580; SB203580; SB203580; SB 203580; RWJ-64809; PB-203580; RWJ64809; PB203580;

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 1 g

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