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RO1138452

RO1138452

Item no.	V3669-500mg
Manufacturer	InvivoChem LLC
CASRN	221529-58-4
Amount	500 mg
Quantity options	100 mg 10 mg 250 mg 25 mg 50 mg 5 mg
Category	Reagents & Chemicals Molecules
Type	Biochemicals
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Available
Description	InvivoChem Cat #:V3669CAS #:221529-58-4Purity >=98% Description: RO1138452 is a novel, potent and selective antagonist of the IP (prostacyclin) receptor. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3+/-0.1; in a recombinant IP receptor system, pKi is 8.7+/-0.06. RO1138452 possesses analgesic and anti-inflammatory potential. RO1138452 (1-10?mg/kg, i.v.) significantly reduces acetic acid-induced abdominal constrictions. RO1138452 (3-100?mg/kg, p.o.) significantly reduces carrageenan-induced mechanical hyperalgesia and edema formation. One?hour after administration of RO1138452 (5?mg/kg, i.v.) to rats, the total plasma concentration is 0.189 ?ug/mL, whereas the free plasma concentrations is calculated to be 0.009?ug/mL (28 nM). References: Br J Pharmacol. 2006 Feb; 147(3):335-45.; J Pharmacol Exp Ther. 2008 Feb; 324(2):815-26.
	Name: RO-1138452 CAS#: 221529-58-4 Chemical Formula: C19H23N3O Exact Mass: 309.1841 Molecular Weight: 309.41 Elemental Analysis: C, 73.76; H, 7.49; N, 13.58; O, 5.17
Storage	-20C for 3 years in powder form
	-80C for 2 years in solvent
Technical Information	Synonym: RO-1138452; RO1138452; RO 1138452. Chemical Name: N-(4-(4-isopropoxybenzyl)phenyl)-4, 5-dihydro-1H-imidazol-2-amine4, 5-Dihydro-N-(4-((4-(1-methylethoxy)phenyl)methyl)phenyl)-1H-imadazol-2-amine InChi Key: GYYRMJMXXLJZAB-UHFFFAOYSA-N InChi Code: InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10, 14H, 11-13H2, 1-2H3, (H2, 20, 21, 22) SMILES Code: CC(OC1=CC=C(C=C1)CC2=CC=C(NC3=NCCN3)C=C2)C

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 mg

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